Then, Boot your PC from the Installation Media you just created (change Boot Order in your BIOS) To download the Media Creation Tool (Click on Download Tool Now), with that you can download the latest Windows 10 ISO (Select Create Installation Media for Another PC), you can create a bootable USB flash drive (min 4GB) using that tool or create the ISO file which you can later burn to DVD I would clean install Windows 10 and then install clean drivers, since the drivers in your other drive may not be compatible with the new version of Windows 10 Since you previously had Windows 10 installed and activated on that PC during the installation process skip the steps which ask for a product key and select the option 'I am Reinstalling Windows 10 on this PC', and activation will not be an issue, your PC will have a digital entitlement stored on the Microsoft Activation Servers
Hi Robert, activation will not be an issue when you re-install Windows 10, it is only when you replace your motherboard that issues arise